I just reserved my place at PyCon UK 2008, which will again be held at the Birmingham Conservatoire on the second weekend of September (12/13/14). If you like Python and you can make it, you should: the vibe last year was great, the talks interesting, and the organisers a nice bunch of geeks. The extra-early-bird offer expires on June 9, so be quick and you could save a few pounds!
If you come, take a minute to RSVP on the official PyConUK 2008 Facebook event page; the more people there, the better visibility (and credibility) we get. Also, if you are on other social networks, you can do something similar to aggregate interested people.
Unfortunately I can't make the Friday tutorials (I'm saving days for a big trip to Japan in October), but I'm sure Saturday and Sunday won't be disappointing. See you there!